Browsing by Subject "cancer"
Now showing items 1-20 of 29
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(2014-10-14)Cancer is a group of diseases characterized by uncontrolled cell proliferation. Cancer is responsible for nearly 1 of every 4 deaths, and ranks as the second highest cause of death worldwide, and costs the American population ...
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(2020-04-13)Tissue engineered 3D cell culture models have shown promise investigating the influence of the tumor microenvironment on cancer cell behavior. Synthetic hydrogels, such as those made from poly(ethylene glycol) (PEG), can ...
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(2019-04-24)A number of cancers disseminate first through the lymphatic system, and the presence of tumor cells in the sentinel or draining lymph node is a major prognostic indicator. Head and neck cancers (HNSCC) which preferentially ...
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Specifically targeting cancer cells is much more efficient than non-targeted treatment because it decreases side effects and permits stronger treatment without as a risk of harming normal cells. Smart molecular probes and ...
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(2014-05-06)p27 is a critical CDK inhibitor involved in cell cycle regulation, but its response to DNA damage remains unclear. Constitutive photomorphogenesis 1 (COP1), a p53- targeting E3 ubiquitin ligase, is downregulated by DNA ...
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(2020-06-15)Cancer is the second major cause of death in the US which exerts significant morbidity, mortality and economic burden. In this dissertation I focused on the financial toxicity of cancer. I conducted three studies examining ...
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(2008-05-21)When prototrophic yeast cells undergo continuous growth in nutrient-limited conditions, they experience robust metabolic oscillations. Additionally, the processes of metabolism in yeast cells have been shown to be coordinated ...
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(1989)Humans and laboratory animals experience a decline in immune system function and DNA excision repair correlated with increased occurrence of cancer as a function of age. Dietary restriction is reported to be associated ...
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(2009-05-15)To evaluate the anticancer potential of sorghum phenolic compounds, different experiments including in vitro and in vivo tests were performed. A set of 25 sorghum samples was evaluated for phenolic (total phenols, flavonoids, ...
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(2014)Of cancers affecting both men and women, colorectal cancer (CRC) is the second leading cancer killer among African Americans in the U.S. Compared to White men, African American men have incidence and mortality rates 25% ...
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(2012-06-08)Breast cancer is the most common cancer in women and is predominantly estrogen dependent [1]. About 1 in 8 women in the United States (12%) will develop invasive breast cancer over the course of her lifetime. Failure in ...
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(2012-05-09)Cyclin-Dependent Kinase 8 (CDK8) has recently emerged as an oncoprotein that is amplified in both colorectal and melanoma cancers. The importance of CDK8 and its regulatory partner Cyclin C (CycC) is highlighted by the ...
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(2016-04-26)Eosinophils have numerous functions for defense against pathogens, despite being only 1-5% of total circulating blood leukocytes. Most well known for their actions contributing to asthma and allergic disease, eosinophils ...
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(2014-07-25)As of January 1, 2012, an estimated 13.7 million cancer survivors were alive in the United States. The number of cancer survivors is expected to reach 18 million by the year 2022. Adolescent and Young Adult (AYA) cancer ...
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Inactivation or mutation of phosphatase and tensin homolog (PTEN), a tumor suppressor gene, is implicated in unregulated cell proliferation, leading to tumor growth and the development of cancer. Identification of modifier ...
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(2013-09-25)Prostate cancer is the second most common form of cancer in American men. Though broad treatments are available, these often have deleterious effects on the patient. One approach which may result in a more tailored treatment ...
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(2013-05-03)The objectives of this thesis are to produce radioactive antibody-conjugated gold nanoparticles to improve the efficacy of targeted radionuclide therapy for the treatment of cancer, and to demonstrate that this product can ...
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(Texas A&M University, 2006-04-12)Fruits and vegetables are known to play an important role in human health due to the range of phytochemicals they contain. Twenty-one peach genotypes and 45 plum genotypes with different flesh and skin color were analyzed ...
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(2014-07-10)The purpose of this dissertation study was to identify previvors’ sources of uncertainty and strategies for managing uncertainty and understand how previvors’ uncertainty influence what type of preventative health decisions ...